A metaplasia escamosa em dpoc: uma revisão sistemática

Authors

  • Daniela Sasso Pasquini
  • Isabella Vieira Laporte Ambrozewicz
  • Sofia Garcia Santana

DOI:

https://doi.org/10.46919/archv5n1-037

Keywords:

células escamosas, carcinoma brônquico, DPOC, fumantes

Abstract

Introdução: A Doença Pulmonar Obstrutiva Crônica (DPOC) é caracterizada por uma obstrução persistente do fluxo de ar nos pulmões e tem o tabagismo como principal agente etiológico. Entre as alterações do tecido pulmonar que ocorrem na doença, se destaca a metaplasia escamosa, remodelamento tecidual a partir de estímulos externos, que pode causar carcinoma brônquico. Objetivo: demostrar aspectos e características da metaplasia escamosa na DPOC. Método: Foi realizada uma revisão sistemática nas bases de dados Pubmed, MedLine e Cochrane Library utilizado os descritores: "(("metaplasia"[MeSH Terms] OR metaplasia[Text Word]) AND ("pulmonary disease, chronic obstructive"[MeSH Terms] OR COPD[Text Word]))", "(Squamous Metaplasia AND COPD)", "(Smokers AND COPD)". Foram excluídos artigos irrelevantes e que não foram publicados nos últimos 10 anos. Resultado: A metaplasia escamosa em DPOC ocorre a partir da troca do tecido epitelial pseudoestratificado por escamoso, pela exposição aos gases do tabaco. Além disso, ocorre aumento de eosinófilos e em média 60% dos pacientes com DPOC apresentam esse tipo de metaplasia. Foi analisado também que a fumaça do cigarro influencia no desenvolvimento de carcinomas brônquicos. Conclusão: Na DPOC ocorre substituição de epitélio pseudoestratificado por escamoso, aumento da metaplasia escamosa e expressão de marcadores de carconogênese. A escassez de estudos sobre esse fenômeno é preocupante, especialmente considerando que a maioria dos pacientes são fumantes. Mais pesquisas são necessárias para entender e tratar melhor essa condição prevalente.

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Published

2024-03-26

How to Cite

PASQUINI, D. S.; AMBROZEWICZ, I. V. L.; SANTANA, S. G. A metaplasia escamosa em dpoc: uma revisão sistemática. Journal Archives of Health, [S. l.], v. 5, n. 1, p. 399–403, 2024. DOI: 10.46919/archv5n1-037. Disponível em: https://ojs.latinamericanpublicacoes.com.br/ojs/index.php/ah/article/view/1616. Acesso em: 14 apr. 2024.