Potencial terapêutico de antioxidantes no tratamento da hipertensão – uma revisão da literatura

Authors

  • Vinicius Teixeira Honório dos Santos
  • Fernando Henrique da Silva
  • Filipe Nogueira Franco

DOI:

https://doi.org/10.46919/archv4n4-006

Keywords:

Hipertensão, doenças crônicas, estresse oxidativo, antioxidantes

Abstract

A hipertensão é uma das doenças crônicas de maior prevalência no mundo, com aproximadamente 15% da população mundial. Numerosos estudos suportam a contribuição do estresse oxidativo na patogênese da hipertensão, sendo que antioxidantes têm papel importante para evitar o acúmulo dessas moléculas reativas. Com isso, o objetivo do estudo foi realizar uma revisão integrativa sobre os principais antioxidantes que vêm sendo estudados na pesquisa clínica para o tratamento da doença. Foram selecionadas 25 publicações. As vitaminas C e E se destacam pela quantidade de pesquisas sobre, e também, pelo grande número de ensaio clínicos onde apresentaram resultados benéficos para a pressão sanguínea. Também foram encontrados artigos que testam a suplementação com chá verde, o chá preto ou chá azedo. Em geral, os chás se mostraram eficientes na diminuição da pressão sanguínea dos pacientes, inclusive em hipertensos. Apesar disso, destaca-se que os antioxidantes não são agentes que possam substitutos as terapias medicamentosas prescritas ou os hábitos de vida saudáveis em geral. Em vez disso, ele desemprenha um papel complementar a esses dois fatores. Eles devem ser incorporados como um componente adicional nos cuidados da saúde e estilo de vida voltadas para o tratamento da hipertensão.

References

AMPONSAH-OFFEH, M. et al. Oxidative Stress, Antioxidants and Hypertension. Antioxidants, v. 12, n. 2, p. 281, 27 jan. 2023.

ARAÚJO, V.S. et al. Aspectos epidemiológicos e citopatológicos de infecções pelo Papilomavírus Humano (HPV) em adolescentes cearenses. In book: Saúde Coletiva: Solução de Problemas e Qualificação do Profissional, 2020.

BIESINGER, S. et al. A combination of isolated phytochemicals and botanical extracts lowers diastolic blood pressure in a randomized controlled trial of hypertensive subjects. European Journal of Clinical Nutrition, v. 70, n. 1, p. 10–16, 10 jun. 2015.

CHEN, X. et al. Antioxidant Effects of Vitamins C and E Are Associated With Altered Activation of Vascular NADPH Oxidase and Superoxide Dismutase in Stroke-Prone SHR. Hypertension, v. 38, n. 3, p. 606–611, set. 2001.

DAYEM, A. et al. The Role of Reactive Oxygen Species (ROS) in the Biological Activities of Metallic Nanoparticles. International journal of molecular sciences, v. 18, n. 1, p. 120, 2017.

DRAIJER, R. et al. Consumption of a Polyphenol-Rich Grape-Wine Extract Lowers Ambulatory Blood Pressure in Mildly Hypertensive Subjects. Nutrients, v. 7, n. 5, p. 3138–3153, 30 abr. 2015.

EMAMI, M. R. et al. Effect of vitamin E supplementation on blood pressure: a systematic review and meta-analysis. Journal of Human Hypertension, v. 33, n. 7, p. 499–507, 7 mar. 2019.

GHEZZI, P. et al. The oxidative stress theory of disease: levels of evidence and epistemological aspects. British Journal of Pharmacology, v. 174, n. 12, p. 1784–1796, 4 ago. 2016.

GUAN, Y.; DAI, P.; WANG, H. Effects of vitamin C supplementation on essential hypertension. Medicine, v. 99, n. 8, 21 fev. 2020.

HALLIWELL, B. How to Characterize an Antioxidant- An Update. Biochem Soc Symp., v.61, p.73-101, 1995.

HODGSON, J. M. et al. Effects of vitamin E, vitamin C and polyphenols on the rate of blood pressure variation: results of two randomised controlled trials. British Journal of Nutrition, v. 112, n. 9, p. 1551–1561, 19 set. 2014.

HOFMANN, A.; BRUNSSEN, C.; MORAWIETZ, H. Contribution of lectin-like oxidized low-density lipoprotein receptor-1 and LOX-1 modulating compounds to vascular diseases. Vascular Pharmacology, p. S1537-1891(17)301714, 19 out. 2017.

KELISHADI, M. et al. Lycopene Supplementation and Blood Pressure: Systematic review and meta-analyses of randomized trials. Journal of Herbal Medicine, v. 31, p. 100521, fev. 2022.

KIRCH, N. et al. A nutritive dose of pure (–)-epicatechin does not beneficially affect increased cardiometabolic risk factors in overweight-to-obese adults—a randomized, placebo-controlled, double-blind crossover study. The American Journal of Clinical Nutrition, v. 107, n. 6, p. 948–956, 1 jun. 2018.

LI, G. et al. Effect of green tea supplementation on blood pressure among overweight and obese adults: a protocol for a systematic review. BMJ Open, v. 4, n. 4, p. e004971, abr. 2014.

LI, X.; XU, J. Lycopene Supplement and Blood Pressure: An Updated Meta-Analysis of Intervention Trials. Nutrients, v. 5, n. 9, p. 3696–3712, 18 set. 2013.

LOBO, V. et al. Free radicals, antioxidants and functional foods: Impact on human health. Pharmacogn Rev. v.4, n.8, p.118-26, 2010.

LUFT, F.C. Twins in cardiovascular genetic research. Hypertension, v.37, p.350–356, 2001.

MAHDAVI-ROSHAN, M. et al. The effects of regular consumption of green or black tea beverage on blood pressure in those with elevated blood pressure or hypertension: A systematic review and meta-analysis. Complementary Therapies in Medicine, v. 51, p. 102430, jun. 2020.

MARQUES, B. C. A. A. et al. Beneficial effects of acute trans-resveratrol supplementation in treated hypertensive patients with endothelial dysfunction. Clinical and Experimental Hypertension, v. 40, n. 3, p. 218–223, 12 fev. 2018.

MILLS, K.T.; STEFANESCU, A.; HE, J. The global epidemiology of hypertension. Nat Rev Nephrol., v.16, n.4, p.223-237, 2020.

MOHAMMADI, V. et al. Does alpha-lipoic acid supplementation modulate cardiovascular risk factors in patients with stroke? A randomized, double-blind clinical trial. International Journal of Preventive Medicine, v. 9, n. 1, p. 34, 2018.

MOHAMMADI, V. et al. The effect of alpha-lipoic acid (ALA) supplementation on cardiovascular risk factors in men with chronic spinal cord injury: a clinical trial. Spinal Cord, v. 53, n. 8, p. 621–624, 10 mar. 2015.

MOHAMMADI, V.; ASKARI, G.; DEHGHANI, S. Does alpha-lipoic acid supplement regulate blood pressure? A systematic review of randomized, double-blind placebo-controlled clinical trials. International Journal of Preventive Medicine, v. 8, n. 1, p. 33, 2017.

MOZAFFARI-KHOSRAVI, H.; AHADI, Z.; BARZEGAR, K. The Effect of Green Tea and Sour Tea on Blood Pressure of Patients with Type 2 Diabetes: A Randomized Clinical Trial. Journal of Dietary Supplements, v. 10, n. 2, p. 105–115, jun. 2013.

NDIAYE, M. et al. Red wine polyphenols cause endothelium-dependent EDHF-mediated relaxations in porcine coronary arteries via a redox-sensitive mechanism. Biochemical and Biophysical Research Communications, v. 310, n. 2, p. 371–377, out. 2003.

NOGUEIRA, L. DE P. et al. Short-term Effects of Green Tea on Blood Pressure, Endothelial Function, and Metabolic Profile in Obese Prehypertensive Women: A Crossover Randomized Clinical Trial. Journal of the American College of Nutrition, v. 36, n. 2, p. 108–115, 31 out. 2016.

OPARIL, S. et al. Hypertension. Nat Rev Dis Primers, v.4, p.18014, 2018.

OYEWOLE, A. O.; BIRCH-MACHIN, M. A. Mitochondria-targeted antioxidants. FASEB journal: official publication of the Federation of American Societies for Experimental Biology, v. 29, n. 12, p. 4766–4771, 1 dez. 2015.

PENG, X. et al. Effect of green tea consumption on blood pressure: A meta-analysis of 13 randomized controlled trials. Scientific Reports, v. 4, n. 1, 1 set. 2014.

RAS, R. T. et al. Effect of polyphenol-rich grape seed extract on ambulatory blood pressure in subjects with pre- and stage I hypertension. v. 110, n. 12, p. 2234–2241, 1 dez. 2013.

RODRIGO, R. et al. Oxidative stress-related biomarkers in essential hypertension and ischemia-reperfusion myocardial damage. Dis Markers, v.35, n.6, p.773-90, 2013.

RODRIGO, R.; GONZÁLEZ, J.; PAOLETTO, F. The role of oxidative stress in the pathophysiology of hypertension. Hypertens Res., v.34, p.431–440, p.2011.

RUECKSCHLOSS, U.; DUERRSCHMIDT, N.; MORAWIETZ, H. NADPH Oxidase in Endothelial Cells: Impact on Atherosclerosis. Antioxidants & Redox Signaling, v. 5, n. 2, p. 171–180, abr. 2003.

SERBAN, M. et al. Effects of Quercetin on Blood Pressure: A Systematic Review and Meta‐Analysis of Randomized Controlled Trials. Journal of the American Heart Association, v. 5, n. 7, 6 jul. 2016.

SIES, H. Strategies of antioxidant defense. European Journal of Biochemistry, v. 215, n. 2, p. 213–219, jul. 1993.

SILVA-E-OLIVEIRA, J. et al. Low-dose resveratrol supplementation on heart rate variability in hypertensive volunteers: a controlled double-blind trial. MedicalExpress, v. 3, n. 6, p. M160606, nov. 2016.

TERAUCHI, M. et al. Effects of grape seed proanthocyanidin extract on menopausal symptoms, body composition, and cardiovascular parameters in middle-aged women. Menopause, v. 21, n. 9, p. 990–996, set. 2014.

ÜLKERS.; MCKEOWN, P. P.; BAYRAKTUTAN, U. Vitamins Reverse Endothelial Dysfunction Through Regulation of eNOS and NAD(P)H Oxidase Activities. Hypertension, v. 41, n. 3, p. 534–539, mar. 2003.

World Health Organization. Hypertension. Disponível em: <https://www.who.int/news-room/fact-sheets/detail/hypertension> Acesso em 07 de abril de 2023.

XU, R. et al. Effect of green tea supplementation on blood pressure. Medicine, v. 99, n. 6, p. e19047, fev. 2020.

YUAN, X. et al. Effects of vitamin C supplementation on blood pressure and hypertension control in response to ambient temperature changes in patients with essential hypertension. 1 jan. 2019.

ZAHEDI, M. et al. Does Quercetin Improve Cardiovascular Risk factors and Inflammatory Biomarkers in Women with Type 2 Diabetes: A Double-blind Randomized Controlled Clinical Trial. International Journal of Preventive Medicine, v. 4, n. 7, p. 777–785, 1 jul. 2013.

ZHANG, Z. et al. Effect of Pycnogenol Supplementation on Blood Pressure: A Systematic Review and Meta-analysis. Iranian Journal of Public Health, v. 47, n. 6, p. 779–787, 1 jun. 2018.

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Published

2023-10-29

How to Cite

DOS SANTOS, V. T. H.; DA SILVA, F. H.; FRANCO, F. N. Potencial terapêutico de antioxidantes no tratamento da hipertensão – uma revisão da literatura. Journal Archives of Health, [S. l.], v. 4, n. 4, p. 1155–1170, 2023. DOI: 10.46919/archv4n4-006. Disponível em: https://ojs.latinamericanpublicacoes.com.br/ojs/index.php/ah/article/view/1413. Acesso em: 23 may. 2024.